Nikolaos Karathanos was born in Athens in 1967. He studied at the Pedagogical Academy of Rhodes and at the National Theatre of Greece Drama School.

His directing work includes the following:
  • 2006 "Julius Caesar" by W. Shakespeare, National Theatre of Greece
  • 2008 "Eight Women" by R. Thomas, Athens and Epidaurus Festival
  • 2010 "Cyrano de Bergerac" by E. Rostand, National Theatre of Greece
  • 2012 Opening Ceremony at the Ancient Theatre of Delphi
  • 2013 "Golfo" by S. Peressiadis, National Theatre of Greece
  • 2014 "Decameron - An adaption on Boccaccio's play", National Theatre of Greece
  • 2015 "Cherry Orchard" by A. Chekhov, Onassis Cultural Center
  • 2015 "Salome" based on the oratorio San Giavoanni Battista by Alessandro Stradella, Athens and Epidaurus Festival
  • 2016 "Birds" by Aristophanes, Ancient Theater of Epidaurus & Onassis Cultural Center
  • 2017-2018 "Operetta" by W. Gombrowicz, National Theatre of Greece
  • 2018 "Birds" by Aristophanes, St. Ann's Warehouse - Brooklyn, NY
  • 2021 "Prometheus" by Aeschylus “Prometheus Bound”, Onassis Cultural Center

He has received many awards for his work, both himself and the members of his group.
He has collaborated with the National Theater of Greece, the Greek National Opera, the Athens and Epidaurus Festival, as well as with numerous private and regional theaters, but also with Getty Museum, Los Angeles.

As an actor, he has collaborated with the directors Anatoli Vassiliev, Dimiter Gotscheff, Yorgos Lanthimos, Yoshi Viler, Matthias Langhoff, Yannis Houvardas, Michael Marmarinos, Dimitris Mavrikios, Vasilis Papavasiliou.
He has played the leading role in many performances of the classical and contemporary repertory and has taken part in tours in Greece and all over the world.

Karathanos teaches at the National Theater of Greece Drama School (Stage Direction Department) and has taught at the University UCRA, Rio de Janeiro.